Chiney Ogwumike scored 24 of her 32 points in the first half and No. 6 Stanford won its eighth straight, beating New Mexico 74-41 on Monday night.
Mikaela Ruef had 10 rebounds and blocked three shots for the Cardinal (9-1), who host No. 3 Tennessee on Saturday.
Bryce Owens scored 12 points, all on 3-pointers, to lead the Lobos (4-5), who fell to 2-11 against teams ranked in the top 10.
New Mexico, which ranks second in the Mountain West Conference in scoring defense and first in rebounding margin, last beat a top 10 team eight years ago.