San Francisco Giants closer Santiago Casilla allowed a solo home run to Nolan Arenado to lead off the bottom of the ninth inning.
Keeping his embattled closer on a short leash, manager Bruce Bochy pulled Casilla with two outs and a man on first. The skipper went to Josh Osich, who hit Charlie Blackmon with a pitch.
Bochy once again walked out to the mound and brought in the recently called-up Joe Nathan, who promptly surrendered a single to Nick Hundley and a game-winning double to Christhian Adames. The Rockies won the game, 6-5.
Starter Albert Suarez pitched ably, throwing five innings while allowing three runs on six hits and a walk. The offense even got on track, knocking 13 hits in the hitter-friendly Coors Field. But it was all wasted by a dismal ninth inning.
Wednesday marked yet another frustrating series loss for the Giants, who dropped two of three against the Rockies.