George Kittle in Mexico City

San Francisco 49ers tight end George Kittle celebrates after scoring a touchdown during the second half of an NFL football game against the Arizona Cardinals, Monday, Nov. 21, 2022, in Mexico City.

Jimmy Garoppolo threw four touchdowns as 78,427 fans in Mexico City witnessed the San Francisco 49ers blowout of the Arizona Cardinals in the NFL's final international game of the season. 

Brandon Aiyuk, George Kittle and Deebo Samuel took the ball into the end zone and helped San Francisco pull away in the second half. For the third-straight game, the team's defense held their opposition to zero points in the second half. 

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